Three pioneers win chemistry Nobel Prize

Martin Karplus, Michael Levitt and Arieh Warshel have won the Nobel Prize in chemistry.

Martin Karplus, Michael Levitt and Arieh Warshel have won 2013’s Nobel Prize in chemistry. Picture: AFP

STOCKHOLM - Three US scientists won the Nobel chemistry prize on Wednesday for pioneering work on computer programs that simulate complex chemical processes and have revolutionised research in areas from drugs to solar energy.

The Royal Swedish Academy of Sciences, awarding the prize of £783 000 to Martin Karplus, Michael Levitt and Arieh Warshel, said their work had effectively taken chemistry into cyberspace. Long gone were the days of modelling reactions using plastic balls and sticks.

"Today the computer is just as important a tool for chemists as the test tube," the academy said in a statement. "Computer models mirroring real life have become crucial for most advances made in chemistry today.

"Chemical reactions occur at lightning speed; electrons jump between atomic nuclei, hidden from the prying eyes of scientists," the academy added.

In drug design, for example, researchers can now use computers to calculate how an experimental medicine will react with a particular target protein in the body by working out the interplay of atoms.

Today, all pharmaceutical companies have sections dedicated to predicting by computer modelling how a drug molecule will interact with the body.

But the approach also has applications in industrial processes, such as the design of solar cells or catalysts used in cars. For the former, programs can be used to mimic the process of photosynthesis by which green leaves absorb sunlight and produce oxygen.

Ultimately, the ability to computerise such complex chemical processes might make it possible to simulate a complete living organism at the molecular level - something Levitt has described as one of his dreams.

Karplus, a US and Austrian citizen, carries out research at the University of Strasbourg and Harvard University. Levitt, a US and British citizen, is at the Stanford University School of Medicine.

Warshel, a US and Israel citizen, is a professor at the University of Southern California, Los Angeles.

Chemistry was the third of this year's Nobel prizes. The prizes for achievements in science, literature and peace were first awarded in 1901 in accordance with the will of businessman and dynamite inventor Alfred Nobel.

"It has revolutionised chemistry," Kersti Hermansson, professor in organic chemistry at Uppsala University, said of the computer modelling.