The 25-year-old fullback needs a scan on a suspected fractured cheekbone.
The Springboks were gutted about losing their tour-opener when Ireland beat the Boks 29-15.
New names include Seabelo Senatla, Robbie Coetzee, Julian Redelinghuys, Jaco Kriel & Nizaam Carr.
The 31-year-old will become the fourth Springbok and 33rd player overall to play in 100 Tests.
Jean de Villiers says Damian de Allende and Handre Pollard are talented individuals who will do well.
Victor Matfield will captain the Boks in the absence of Jean de Villiers.